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. 2019 Apr 2;10:296. doi: 10.3389/fphar.2019.00296

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Copyright © 2019 Vitale, Cavalli, Colafrancesco, Priori, Valesini, Argolini, Baldissera, Bartoloni, Cammelli, Canestrari, Sota, Cavallaro, Massaro, Ruscitti, Cipriani, De Marchi, De Vita, Emmi, Ferraccioli, Frassi, Gerli, Gremese, Iannone, Lapadula, Lopalco, Manna, Mathieu, Montecucco, Mosca, Piazza, Piga, Pontikaki, Romano, Rossi, Rossini, Silvestri, Stagnaro, Talarico, Tincani, Viapiana, Vitiello, Galozzi, Sfriso, Gaggiano, Rigante, Dagna, Giacomelli and Cantarini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan–Meier survival curves describing the cumulative retention of Anakinra over the whole follow-up period taking into account all causes of treatment withdrawal (blue line), only adverse events and lack/loss of efficacy (green line), and only lack and loss of efficacy (red line). The “time 0” is represented by the start of ANA treatment; the “event” corresponds to treatment withdrawal.