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(A) The tumor necrosis factor α (TNFα) secretion in ex vivo human cerebral adrenoleukodystrophy (cALD) monophagocytic cells in dose response to very long-chain fatty acid (VLCFA) stimulation. The labeled doses show C24:0 levels. The C26:0 level is 1/10th of the C24:0 dose. (B) Healthy control, adrenomyeloneuropathy (AMN), and cerebral response to lipopolysaccharide (LPS) and VLCFA stimulation.
