Table 1.
Efficiency of MSA transmission to Tg(SNCA) mice.
| Patient Sample | TgM83+/− | Tg(SNCA+/+)Nbm | Tg(SNCA*A30P+/+)Nbm | Tg(SNCA*A53T+/+)Nbm | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F | M | n/n0 | F | M | n/n0 | F | M | n/n0 | F | M | n/n0 | |
| C2 | 8 | 4 | 0/12 | 4 | 3 | 0/7 | 4 | 4 | 0/8 | 4 | 3 | 0/7 |
| C3 | - | - | n.d. | 4 | 4 | 0/8 | 4 | 4 | 0/8 | 4 | 4 | 0/8 |
| C14 | 0 | 8 | 0/8 | 3 | 4 | 0/7 | 4 | 4 | 0/8 | 4 | 4 | 0/8 |
| C16 | - | - | n.d. | 4 | 4 | 0/8 | 4 | 4 | 0/8 | 4 | 4 | 0/8 |
| C17 | - | - | n.d. | 4 | 4 | 0/8 | 4 | 4 | 0/8 | 4 | 4 | 0/8 |
| MSA6 | 4 | 4 | 8/8 | 4 | 4 | 0/8 | 4 | 4 | 0/8 | 4 | 3 | 7/7 |
| MSA13 | 3 | 5 | 8/8 | 3 | 4 | 0/7 | 4 | 4 | 0/8 | 4 | 4 | 7/8 |
| MSA16 | - | - | n.d. | 2 | 4 | 0/6 | 4 | 3 | 0/7 | 3 | 4 | 4/7 |
| MSA17 | 6 | 3 | 9/9 | 4 | 4 | 0/8 | 4 | 4 | 0/8 | 4 | 4 | 2/8 |
| MSA18 | 4 | 4 | 8/8 | 4 | 4 | 0/8 | 4 | 4 | 1/8 | 4 | 4 | 3/8 |
| [C2]* | 8 | 8 | 0/16 | - | - | n.d. | - | - | n.d. | 6 | 5 | 0/11 |
| [MSA6]* | 8 | 8 | 15/16 | - | - | n.d. | - | - | n.d. | 6 | 5 | 5/11 |
| [MSA13]* | 8 | 7 | 13/15 | - | - | n.d. | - | - | n.d. | 7 | 8 | 2/15 |
F, number of female mice inoculated; M, number of male mice inoculated; n, number of affected mice; n0, number of inoculated mice; n.d., not determined.
*
[Samples] indicate human patient samples passaged either in TgM83+/− mice and inoculated in Tg(SNCA*A53T+/+) animals or passaged in Tg(SNCA*A53T+/+) mice prior to inoculating in TgM83+/− animals.