Table 1.
Baseline patient characteristics by isolated diastolic hypertension
| n (%) or mean (±SD) | Isolated diastolic hypertension
|
||
|---|---|---|---|
| No (n=497) |
Yes (n=27) |
P value | |
| Age (years) | 71 (±5) | 71 (±6) | 0.927 |
| Female | 293 (59%) | 12 (44%) | 0.137 |
| African American | 38 (8%) | 10 (37%) | <0.001 |
| Annual household income ≥$25,000 | 227 (46%) | 13 (48%) | 0.802 |
| Smoking (pack-year) | 18 (±27) | 16 (±25) | 0.722 |
| Alcohol (drinks/week) | 2 (±4) | 4 (±7) | 0.077 |
| Instrumental ADL | 0.24 (±0.6) | 0.52 (±0.9) | 0.024 |
| Time to walk 15 feet (seconds) | 5 (±1) | 6 (±2) | 0.034 |
| Body mass index (kg/m2) | 25 (±4) | 29 (±4) | <0.001 |
| Acute myocardial infarction | 12 (2%) | 3 (11%) | 0.008 |
| Diabetes mellitus | 28 (6%) | 6 (22%) | 0.001 |
| Pulse (beats per minute) | 68 (±10) | 72 (±13) | 0.034 |
| Systolic BP (mm Hg) | 111(±6) | 132 (±6) | <0.001 |
| Diastolic BP (mm Hg) | 67 (±5) | 94 (±5) | <0.001 |
| LV hypertrophy | 2 (0.4%) | 0 (0%) | 0.741 |
| LVEF 55% or higher | 481 (97%) | 22 (82%) | <0.001 |
| Serum creatinine (mg/dl) | 0.9 (±0.2) | 0.9 (±0.2) | 0.587 |
| Serum uric acid (mg/dl) | 5.2 (±1.3) | 6.0 (±1.6) | 0.002 |
| Serum C-reactive protein | 3.3 (±7.0) | 6.5 (±7.3) | 0.017 |
| Serum insulin | 13 (±10) | 19 (±11) | 0.005 |
| ACE inhibitor or ARB use | 0 (0%) | 2 (7%) | <0.001 |
| Beta-blocker use | 0 (0%) | 3 (11%) | <0.001 |
| Thiazide diuretic use | 0 (0%) | 2 (7%) | <0.001 |
| Ca-channel blocker use | 0 (0%) | 6 (22%) | <0.001 |
| Any anti-hypertensive drugs | 0 (0%) | 14 (52%) | <0.001 |
ABBREVIATIONS: ACE=angiotensin converting enzyme; ADL=activities of daily living; ARB= Angiotensin receptor blocker; BMI=body mass index; BP=blood pressure; CABG=coronary artery bypass graft; LVEF=left ventricular ejection fraction