Table I.
Incidence of Clinical Features in the Current Cohort and Comparisons Between Race/Ethnicity Groups
| Feature | Total (n=139) | Caucasian (n=93) | Mixed (n=24) | Non-Caucasian (n=22) | p-valuea |
|---|---|---|---|---|---|
| Macroglossia | 72.7% | 71.0% | 79.2% | 72.7% | 0.724 |
| Tongue Reductionb | 48.4% | 56.5% | 42.1% | 21.4% | 0.050 |
| Abdominal Wall Defects | 65.5% | 66.7% | 62.5% | 63.6% | 0.912 |
| Omphalocele | 20.9% | 26.9% | 4.2% | 13.6% | 0.034* |
| Umbilical Hernia | 37.7% | 31.5% | 50.0% | 50.0% | 0.108 |
| Diastasis Recti | 18.4% | 18.7% | 26.1% | 9.1% | 0.336 |
| Organomegaly | 45.3% | 41.9% | 36.4% | 68.2% | 0.055 |
| Hepatomegaly | 24.6% | 22.8% | 27.3% | 30.0% | 0.758 |
| Nephromegaly | 26.9% | 22.8% | 22.7% | 50.0% | 0.041* |
| Splenomegaly | 13.4% | 13.0% | 9.1% | 20.0% | 0.574 |
| Lateralized Overgrowth | 82.5% | 82.4% | 79.2% | 86.4% | 0.814 |
| Hypoglycemia | 64.5% | 67.4% | 58.3% | 59.1% | 0.602 |
| Transient hypoglycemiac | 62.9% | 71.0% | 57.1% | 30.8% | 0.021* |
| Hyperinsulinismc | 38.6% | 31.1% | 42.9% | 69.2% | 0.035* |
| Pancreatectomyd | 47.1% | 36.8% | 66.7% | 55.6% | 0.371 |
| Ear creases/pits | 70.4% | 71.1% | 69.6% | 68.2% | 0.960 |
| Facial nevus simplex | 49.3% | 52.7% | 47.8% | 36.4% | 0.383 |
| Tumor | 23.4% | 22.8% | 17.4% | 31.8% | 0.509 |
| Placentomegaly | 17.7% | 18.2% | 14.3% | 19.0% | 0.901 |
| Polyhydramnios | 25.4% | 27.3% | 9.5% | 33.3% | 0.161 |
| Preterm Birth (<37 weeks) | 44.2% | 48.4% | 33.3% | 38.1% | 0.345 |
| LGAe | 65.2% | 60.0% | 79.2% | 71.4% | 0.174 |
*
significant at p < .05
a
P values refer to the frequency of each feature between the three subgroups (Caucasian, Mixed, non-Caucasian), so all subgroups are compared at the same time
b
Percentages reported among just those patients with macroglossia
c
Percentages reported among just those patients with hypoglycemia
d
Percentages reported among just those patients with hyperinsulinism
e
Large for gestational age (>90%ile)