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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Am J Med Genet A. 2019 Feb 4;179(4):525–533. doi: 10.1002/ajmg.a.61053

Table II.

Comparison of Clinical Features in Current Cohort to the European/North American Cohort

Feature European/North American Cohort Current Cohort
Overall Caucasian Mixed Non-Caucasian
% % p-value % p-value % p-value % p-value
LGAa 53.6% 65.2% 0.006** 60.0% 0.221 79.2% 0.006** 71.4% 0.093
Preterm Birth (<37 weeks) 32.0% 44.2% 0.005** 48.4% 0.002** 33.3% 0.893 38.1% 0.581
Polyhydramnios 30.7% 25.4% 0.168 27.3% 0.475 9.52% 0.004** 33.3% 0.805
Macroglossia 83.4% 72.7% 0.005** 71.0% 0.010** 79.2% 0.622 72.7% 0.285
Ear creases/pits 51.0% 70.4% <0.001*** 71.1% <0.001*** 69.6% 0.072 68.2% 0.106
Facial Nevus Simplex 51.0% 49.3% 0.687 52.7% 0.746 47.8% 0.768 36.4% 0.178
Abdominal Wall Defect 62.3% 65.5% 0.435 66.7% 0.377 62.5% 0.984 63.6% 0.900
Omphalocele 37.7% 20.9% <0.001*** 26.9% 0.021* 4.17% <0.001*** 13.6% 0.004**
Umbilical Hernia 32.5% 37.7% 0.213 31.5% 0.841 50.0% 0.107 50.0% 0.124
Diastasis Recti 29.4% 18.4% 0.001** 18.7% 0.011* 26.1% 0.727 9.1% 0.004**
Organomegaly 46.2% 45.3% 0.825 41.9% 0.409 36.4% 0.359 68.2% 0.042*
Nephromegaly 23.8% 26.9% 0.427 22.8% 0.825 22.7% 0.908 50.0% 0.034*
Hepatomegaly 18.4% 24.6% 0.098 22.8% 0.317 27.3% 0.372 30.0% 0.284
Splenomegaly 9.5% 13.4% 0.186 13.0% 0.318 9.1% 0.949 20.0% 0.267
Hypoglycemia 47.6% 64.5% <0.001*** 67.4% <0.001*** 58.3% 0.307 59.1% 0.296
Lateralized Overgrowth 40.8% 82.5% <0.001*** 82.4% <0.001*** 79.2% <0.001*** 86.4% <0.001***
Tumor 10.3% 23.4% <0.001*** 22.8% 0.005** 17.4% 0.390 31.8% 0.046*
*

significant at p < .05

**

significant at p < .01

***

significant at p < .001

a

Large for gestational age (>90%ile)