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. Author manuscript; available in PMC: 2019 Apr 9.
Published in final edited form as: J Neurol Neurosurg Psychiatry. 2017 Oct 20;89(1):53–60. doi: 10.1136/jnnp-2017-316799

Figure 2.

Figure 2.

Spread of white matter alterations over time. The distribution of white matter changes at baseline and follow-up scan is shown for 20 C9+ subjects (interval 6.4 ± 2.9 months). (A) Regions of reduced FA compared to healthy controls are shown at baseline in red. At follow-up, additional regions with reduced FA are shown in orange. These regions extend further into fronto-parietal subcortical white matter and anterior limbs of the internal capsule. (B) Regions with increased MD at baseline are shown in blue. At follow-up, additional regions with increased MD, shown in green, extend more posteriorly into parietal lobes and temporal lobes.