Table 2.

Diffusion tensor imaging measures in white matter tracts of interest at baseline visit

		C9+ Diagnosis subgroups
Tract	Healthy controls N=28	Asymptomatic N=7	ALS N=11	ALS-FTD N=7	bvFTD N=3
R CST FA	0.600 ± 0.023	0.604 ± 0.031	0.555 ± 0.034*	0.580 ± 0.055	0.603 ± 0.033
R CST MD	0.703 ± 0.022	0.701 ± 0.011	0.750 ± 0.035*	0.753 ± 0.031*	0.724 ± 0.019
L CST FA	0.593 ± 0.028	0.590 ± 0.020	0.549 ± 0.030*	0.585 ± 0.032	0.584 ± 0.018
L CST MD	0.716 ± 0.021	0.711 ± 0.010	0.754 ± 0.029*	0.768 ± 0.026*	0.741 ± 0.020
R UNC FA	0.435 ± 0.023	0.426 ± 0.009	0.424 ± 0.026	0.414 ± 0.027	0.403 ± 0.018
R UNC MD	0.810 ± 0.022	0.820 ± 0.009	0.836 ± 0.024*	0.876 ± 0.054*	0.883 ± 0.052*
L UNC FA	0.432 ± 0.023	0.428 ± 0.019	0.424 ± 0.028	0.405 ± 0.038	0.412 ± 0.018
L UNC MD	0.814 ± 0.027	0.824 ± 0.013	0.848 ± 0.034*	0.875 ± 0.037*	0.888 ± 0.041*
CCg FA	0.516 ± 0.032	0.525 ± 0.016	0.490 ± 0.025	0.481 ± 0.043	0.484 ± 0.053
CCg MD	0.860 ± 0.039	0.852 ± 0.030	0.914 ± 0.029*	0.991 ± 0.061*	1.002 ± 0.140*
CCpm FA	0.542 ± 0.024	0.540 ± 0.007	0.514 ± 0.024*	0.509 ± 0.037	0.488 ± 0.044*
CCpm MD	0.796 ± 0.036	0.796 ± 0.022	0.840 ± 0.046*	0.906 ± 0.051*	0.965 ± 0.187*
CCm FA	0.582 ± 0.017	0.578 ± 0.020	0.526 ± 0.032*	0.535 ± 0.033*	0.531 ± 0.031*
CCm MD	0.755 ± 0.029	0.766 ± 0.027	0.819 ± 0.052*	0.849 ± 0.037*	0.903 ± 0.162*
CCsp FA	0.611 ± 0.017	0.616 ± 0.013	0.602 ± 0.023	0.608 ± 0.014	0.609 ± 0.013
CCsp MD	0.804 ± 0.031	0.803 ± 0.014	0.836 ± 0.034*	0.869 ± 0.023*	0.826 ± 0.038

^*Differs from healthy controls by ANCOVA (age as covariate), Dunnett’s test, adjusted p < 0.05.

ALS, amyotrophic lateral sclerosis; bvFTD, behavioural variant FTD; CCg, corpus callosum—genu; CCm, corpus callosum—motor; CCpm, corpus callosum—pre-motor; CCsp, corpus callosum—splenium; CST, corticospinal tract; FA, fractional anisotropy; L, left; MD, mean diffusivity; R, right; UNC, uncinate fasciculus.