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. 2018 May 2;148(5):675–684. doi: 10.1093/jn/nxy036

FIGURE 3.

FIGURE 3

Metabolome-wide association study of transcripts in 3 gene sets of mouse liver (from Figure 2) altered by supplemental selenium. Associations between 80 significant genes and the metabolome (12,421 features) from mouse liver (n = 5) are visualized at |ρ| ≥ 0.9, showing 2 central gene hubs and scattered connections (bottom left) and pathway associations of metabolites (bottom right). ACAA1B, peroxisomal 3-oxoacyl-CoA thiolase B; CL, cardiolipin; CPT2, carnitine palmitoyltransferase 2; Dhcr7, 7-dehydrocholesterol reductase; GLUT2, glucose transporter 2; Hmgcr, 3-hydroxy-3-methylglutaryl-CoA reductase; LC, long-chain; PC, phosphatidylcholine; PE, phosphatidylethanolamine; Sc5dl, sterol-C5-desaturase; THC-CoA, 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA; TrHOCCoA, 3α,7α,12α -trihydroxy-5β-24-oxocholestanoyl-CoA.