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. 2019 Apr 5;12:2563–2575. doi: 10.2147/OTT.S190239

Figure 5.

Figure 5

miR-16-5p reverses the effects of silencing of PVT1 in RCC cells.

Notes: (A) Expression of miR-16-5p in RCC cells transfected with NC or miR-16-5p inhibitor. (B) MTT assay showed the proliferation of 786-O and Caki-1 cells transfected with sh-NC or sh-PVT-1 along with NC inhibitor or miR-16-5p inhibitor. (C) PVT1 and miR-199 expression levels were detected by qRT-PCR assays at 48 h after transfection. (D) Migration and (E) Invasion of 786-O and Caki-1 cells were measured by transwell assay after transfection with sh-NC or sh-PVT-1 along with NC inhibitor or miR-16-5p inhibitor. The experiments were repeated three times. The data are expressed as mean ± SD. *P<0.05, **P<0.01 and ***P<0.001.

Abbreviations: NC, negative control; PVT1, plasmacytoma variant translocation 1; qRT-PCR, quantitative real-time PCR; RCC, renal cell carcinoma.