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. 2019 Mar 29;10:619. doi: 10.3389/fmicb.2019.00619

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Copyright © 2019 Fischer and Glass.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of crosstalk between the MAK-2 pathway, the CWI/MAK-1 pathway and the STRIPAK complex. A cyan “P” indicates canonical MAPK cascade phosphorylation, and a yellow “P” indicates MAK-2-dependent phosphorylation. MAPK pathway proteins are purple, the STRIPAK complex is blue, and pink transcription factors (PP-1 and ADV-1) are downstream of all three signaling components. MAK-2 is required for activation or de-repression of PP-1, and MAK-1 regulates ADV-1 in a PP-1-independent manner.