Figure 6.

SIGNET improves PPI density among top ranked genes. For each one of the six complex diseases, including rheumatoid arthritis, Crohn’s disease, schizophrenia, osteoporosis, multiple sclerosis, and ulcerative colitis, we calculated the density of PPI edges for top ranked N genes (from 100 to 2000, step size 100). In each subplot, x-axis and y-axis denote the number of top ranked genes and the density of PPI edges, respectively. Note that the results for P-value and SIGNET (single) are similar for some diseases and corresponding lines are also similar, especially in osteoporosis.