Table 2. Virus neutralization and receptor binding inhibition by anti-MERS-S mAbs.

mAb	MERS-S target	IC50* MERS-S VSVpp		PRNT50** MERS-CoV		RBI50***
		μg/ml	nM	μg/ml	nM	μg/ml	nM
7.7g6	S1B	0.001	0.007	0.008	0.053	0.007	0.047
1.6f9		0.006	0.04	0.03	0.200	0.013	0.087
1.2g5		0.002	0.013	0.03	0.200	0.014	0.093
1.8e5		1.500	10	>1	>6.67	>10	>66.7
4.6e10		0.048	0.320	1	6.667	0.137	0.913
1.10f3	S1A	>10	> 66.7	>1	>6.67	>10	>66.7
1.6c7	S2A	0.367	2.447	1	6.67	>10	>66.7
3.5g6		2.488	16.6	>1	>6.6	>10	>66.7
α-MERS-CTRL	S1B	0.005	0.033	0.03	0.200	0.022	0.147
Iso-CTRL	–	>10	> 66.7	>1	>6.67	–	–

* IC₅₀: mAb concentration resulting in half-maximal infection of MERS-S VSV pseudovirus (MERS-S VSVpp) on Vero cells.

** PRNT₅₀: highest mAb dilution resulting in > 50% reduction in the number of MERS-CoV infected Vero cells.

*** RBI₅₀: mAb concentration of that gives half-maximal receptor binding.