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. 2019 Jan 16;8(1):45–54. doi: 10.1080/22221751.2018.1558962

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Cross-protective efficacy against the hetero-subtypic influenza viruses H9N2, H6N6, and H10N8. M2e DNA immunized mice were infected with a 10 × LD₅₀ dose of each influenza virus. Lungs were collected at day 3 post-infection for virus titration via TCID₅₀ assay. Survival rates (A), virus titers (B) and body weight changes (C) of immunized mice after H9N2 influenza virus infection. Survival rates (D), virus titers (E) and body weight changes (F) of immunized mice after H6N6 influenza virus infection. Survival rates (G), virus titers (H) and body weight changes (I) of immunized mice after H10N8 influenza virus infection. Statistical significance was defined as *p < 0.05.