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Viral growth of the chimeric bat influenza virus PR8-H18N11 is suppressed by MxA in vitro. MDCK-SIAT1 cells overexpressing MxA (dashed line) or MxAT103A (solid line) were infected with (a) PR8, (b) pH1N1, (c) KAN-1 or (d) PR8-H18N11 at an MOI of 0.001 and viral titres were measured at 12, 24, 36, 48 and 60 h post infection by plaque assay. Error bars indicate the standard error of the mean of at least three independent experiments. Dashed line indicates the detection limit.
