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. 2019 Apr 2;10:685. doi: 10.3389/fimmu.2019.00685

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Copyright © 2019 Hazeldine, Dinsdale, Harrison and Lord.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Traumatic injury results in impaired PMA-induced activation of ERK MAPK. Phosphorylation status of ERK 1/2 in resting and PMA-stimulated neutrophils isolated from healthy controls (HC) and trauma patients 4–12 and 48–72 h post-injury. Data are presented as representative Western blots (B) and densitometry analysis of ERK phosphorylation in resting (A) or PMA-stimulated neutrophils at the 4–12 h (C) and 48–72 h (D) post-injury time points. HC (n = 4), 4–12 h (n = 8), and 48–72 h (n = 6). For (C) and (D) ^*p < 0.01, ^**p < 0.001, ^***p < 0.0001 vs. Time 0, ^##p < 0.001, ^###p < 0.0001 vs. HC sample at matched time point.