11.

Non‐serious adverse events up to three months after randomisation. Four trials provided data. The diversity‐adjusted required information size (DARIS) was calculated based on non‐serious adverse events of 5% in the control group; relative risk reduction (RRR) in the glucocorticosteroid group of 50%; type I error of 1%; and type II error of 20% (80% power). Trial diversity was 0%. The required information size was 2698 participants. The cumulative Z‐curve (blue line) did not cross the trial sequential monitoring boundaries for benefit or harm (red inward sloping lines) and did not enter the trial sequential monitoring area for futility (inner‐wedge with red outward sloping lines). The green dotted lines show the conventional boundaries of the naive alpha of 5% equal to Z‐scores of +1.96 and –1.96.