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. 2019 Apr 9;2019(4):CD001511. doi: 10.1002/14651858.CD001511.pub4

Comparison 2. Subgroup analysis: all‐cause mortality up to 3 months' follow‐up after randomisation.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Bias risk 15   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 Trials at low risk 1 1103 Risk Ratio (M‐H, Random, 95% CI) 1.03 [0.84, 1.26]
1.2 Trials at high risk 14 758 Risk Ratio (M‐H, Random, 95% CI) 0.86 [0.63, 1.17]
2 Trials without for‐profit funding compared to trials at risk of for‐profit funding 15 1861 Risk Ratio (M‐H, Random, 95% CI) 0.90 [0.70, 1.15]
2.1 Trials without for‐profit funding 1 1103 Risk Ratio (M‐H, Random, 95% CI) 1.03 [0.84, 1.26]
2.2 Trials at risk of for‐profit funding 14 758 Risk Ratio (M‐H, Random, 95% CI) 0.86 [0.63, 1.17]
3 Severity of alcoholic hepatitis 15   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
3.1 Mild alcoholic hepatitis 4 182 Risk Ratio (M‐H, Random, 95% CI) 1.02 [0.58, 1.80]
3.2 Severe alcoholic hepatitis 14 1679 Risk Ratio (M‐H, Random, 95% CI) 0.92 [0.73, 1.16]
4 Glucocorticosteroid (prednisolone) dose 15   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
4.1 ≤ 40 mg 10 1547 Risk Ratio (M‐H, Random, 95% CI) 0.75 [0.50, 1.14]
4.2 > 40 mg 5 314 Risk Ratio (M‐H, Random, 95% CI) 1.02 [0.79, 1.30]
5 Alcoholic hepatitis without or with cirrhosis 15   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
5.1 Without cirrhosis 3 123 Risk Ratio (M‐H, Random, 95% CI) 0.79 [0.18, 3.48]
5.2 With cirrhosis 12 1738 Risk Ratio (M‐H, Random, 95% CI) 0.92 [0.74, 1.16]
6 Alcoholic hepatitis without or with hepatorenal syndrome 10   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
6.1 With hepatorenal syndrome 8 1382 Risk Ratio (M‐H, Random, 95% CI) 1.00 [0.85, 1.17]
6.2 Without hepatorenal syndrome 2 129 Risk Ratio (M‐H, Random, 95% CI) 0.56 [0.05, 6.49]
7 Alcoholic hepatitis without or with ascites 14   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
7.1 With ascites 13 729 Risk Ratio (M‐H, Random, 95% CI) 0.82 [0.60, 1.12]
7.2 Unclear if they had ascites 1 29 Risk Ratio (M‐H, Random, 95% CI) 2.83 [0.61, 13.06]