Comparison 4. Sensitivity analysis: serious adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Best‐worse scenario of serious adverse events during treatment	15	1861	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.83, 1.21]
2 Worst‐best scenario of serious adverse events during treatment	15	1861	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [1.05, 1.31]