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. 2017 Sep 28;28(11):3868–3879. doi: 10.1093/cercor/bhx248

Figure 1.

Figure 1.

Cntnap2 −/− mice exhibit an increased trend for pERK1/2 in embryonic MGE but no gross changes in MGE-derived CIN numbers or lamination. Western blots from E13.5 MGE tissue lysates showing CASPR2, pERK1/2Thr202/Tyr204, total ERK1/2, pAKTSer473, total AKT, and βIII-tubulin (loading control) (a). (b) quantification of the levels of pAKT or pERK divided by the total amount of AKT or ERK expressed as arbitrary units (AU). (c–e) Immunofluorescence images in coronal sections showing MGE-derived CINs, tdTomato+ and co-labeled with DAPI, in the somatosensory cortex at P30. (f) Quantification of tdTomato+ cell density in the somatosensory cortex at P30. (g) Quantification of the proportion of tdTomato+ cells per lamina at P30. Data are expressed as mean ± SEM. n = 3, all groups. Scale bar in (e) = 100 μm.