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. Author manuscript; available in PMC: 2019 Apr 9.
Published in final edited form as: Science. 2018 Aug 31;361(6405):866–869. doi: 10.1126/science.aat5011

Figure 1 -. Adaptive immunity by CRISPR-Cas systems.

Figure 1 -

a) Foreign genetic elements are acquired by Cas1/Cas2 and integrated into the CRISPR-array in a process broadly termed adaptation. b) The CRISPR array and associated Cas proteins are expressed. The CRISPR array is processed and Cas effector nucleases associate with a crRNA to form an active surveillance complex. c) The Cas effector nucleases target foreign genetic elements complementary to their crRNA leading to target interference and immunity.