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. 2018 Feb 1;218(8):1272–1283. doi: 10.1093/infdis/jiy062

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Figure 7. — Immune complex-FCGR2B inhibitory signaling suppresses the stress responses to simian immunodeficiency virus (SIV) exposure in cervical tissues and maintains expression of cell-cell junction proteins in the epithelium. Pretreating fresh cervical explants of rhesus macaque ex vivo with SIV-specific immune complexes (ICs) before topical application of SIV suppressed the increases of p-p53–expressing nuclei (A) in the mucosa, and maintained to some degree the expression of occludin (OCLN; B) in the epithelium. These inhibitory effects were abrogated when the binding of ICs to FCGR2B was interrupted by blocking antibody (Ab). The nonparametric Wilcoxon signed rank test was used to compare the variations in expression of immunohistochemical markers across different treatment groups. The bars represent standard deviations among repeats in each group.