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. 2018 Feb 1;27(8):1332–1342. doi: 10.1093/hmg/ddy042

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Figure 2. — Immunoblotting analysis of mitochondrial dynamics proteins in 12-month-old APP and non-transgenic WT mice. (A) Shows representative immunoblotting analysis of 12-month-old APP mice. (B) Shows quantitative densitometry analysis of mitochondrial dynamics proteins Drp1, Fis1 (fission) and Mfn1, Mfn2 and Opa1 (fusion) and biogenesis protein PGC1α, NRF1, NRF2 and TFAM. Protein levels of Drp1 (P = 0.002), Fis1 (P = 0.02) were significantly increased; and Mfn1 (P = 0.04), Mfn2 (P = 0.001) and Opa1 (P = 0.04) were significantly decreased in APP mice relative to WT mice. Protein levels of PGC1α (P= 0.01), NRF1 (P = 0.01), NRF2 (P = 0.005) and TFAM (P = 0.03) were significantly decreased in APP mice relative to WT mice.