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Immunoblotting analysis of synaptic and dendritic protein MAP2 in 12-month-old APP and non-transgenic WT mice. (A) Shows representative immunoblotting analysis of 12-month-old APP and WT mice. (B) Shows quantitative densitometry analysis of synaptic and MAP2 proteins. Synaptophysin (P = 0.003), PSD 95 (P = 0.002) and MAP2 (P = 0.04) were significantly decreased in APP mice relative to WT mice.
