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Hippocampal dendritic spine density in 12-month-old APP and non-transgenic WT mice. (A) Represents low magnification of Golgi-cox staining. (B) Represents enlarged neuron with dendrites and (C) represents quantification of spine density in APP and WT mice. Significantly reduced dendritic spines were found in APP mice (P = 0.0003) relative to WT mice, indicating that mutant APP and Aβ levels reduces dendritic spines in APP mice.
