Figure 4: Loss of GluN2B alters OFC firing patterns after error choice.

A. Electrode placement in OFC for GluN2B^NULL and GluN2B^FLOX controls. B. Baseline firing rate of OFC neurons did not differ across genotypes. C. OFC neurons increased firing following a correct choice in both genotypes. Firing decreased from discrimination to early reversal before slowly recovering back to discrimination levels. GluN2B^NULL had slightly reduced firing immediately following response and during reward approach during chance reversal. D. GluN2B^FLOX mice showed an increase in firing following an error choice that increased during early reversal sessions 1 and 3. GluN2B^NULL mice had significantly decreased error firing during discrimination and reversal session 1 and 3 before significantly increasing during reversal session 4. Firing following an error response significantly increased immediately following the choice during chance reversal but did not differ by genotype. Data are means ±SEM. N=8 mice per genotype/recording session. Yellow band indicates reward cue (tone) and grey band error cue (house light). * = p<.01 main effect of time # = p<.01 main effect of genotype ‡ = p<.01 genotype x time interaction