Figure 9: Granger prediction of OFC to dS functional connectivity is significantly increased in GluN2B^NULL mice.

A. Low levels of OFC to dS information transfer immediately after reward cue in GluN2B^FLOX mice, and additionally before reward retrieval in GluN2B^NULL mice. B. The majority of OFC to dS connectivity was shifted to immediately after a correct choice during the first session of reversal in GluN2B^FLOX mice, and this response was blunted in GluN2B^NULL mice, but not significantly. C. GluN2B^FLOX mice maintain OFC to dS connectivity at time of choice during reversal S3, which again is decreased but not significantly in GluN2B^NULL mice. D. GluN2B^FLOX connectivity remains elevated during reversal chance at time of choice on reversal S4, while GluN2B^NULL mice remain to have decreased connectivity. E. Once chance criterion is re-attained Granger prediction in GluN2B^FLOX mice returns to end of reward cue timing at levels similar to those during initial discrimination. However, GluN2B^NULL mice have significantly elevated OFC to dS connectivity on reversal chance. F. Average Granger prediction vales within the Choice and Tone TF-ROIs across sessions. Dotted lines (-----) demarcate choice and offset of associative tone. Black rectangles represent significant effect of genotype. * p<0.05 between genotypes.