Table 1:
Characteristics of Hospitalizations with Severe Sepsis
| Characteristics | Overall (N=117,418) |
No CV Event (N=69,221) |
CV Event Present on Admission (N=16,021) |
Any New- Onset CV Event (N=32,176) |
New- Onset Ischemic Events (N=9,436) |
New- Onset Acute Heart Failure Events (N=6,956) |
New- Onset Arrhythmic Events (N=23,755) |
|---|---|---|---|---|---|---|---|
| Age (years) | 70.8 ± 16.2 | 67.3 ± 17.2 | 78.0 ± 12.9 | 74.8 ± 13.3 | 73.4 ± 14.0 | 75.0 ± 13.3 | 76.0 ± 12.7 |
| Men | 59,187 (50.4%) |
34,100 (49.3%) |
8,095 (50.5%) |
16,992 (52.8%) |
4,882 (51.7%) |
3,439 (49.4%) |
12,585 (54.1%) |
| Race/Ethnicity | |||||||
| White | 69,901 (59.5%) |
38,507 (55.6%) |
10,611 (66.2%) |
20,783 (64.6%) |
5,858 (62.1%) |
4,466 (64.2%) |
15,867 (66.8%) |
| Black | 18,825 (16.0%) |
12,364 (17.9%) |
2,024 (12.6%) |
4,437 (13.8%) |
1,414 (15.0%) |
972 (14.0%) |
2,991 (12.6%) |
| Hispanic | 11,983 (10.2%) |
7,977 (11.5%) |
1,397 (8.7%) |
2,609 (8.1%) |
850 (9.0%) |
631 (9.1%) |
1,789 (7.5%) |
| Other | 16,709 (14.2%) |
10,373 (15.0%) |
1,989 (12.4%) |
4,347 (13.5%) |
1,314 (13.9%) |
887 (12.8%) |
3,108 (13.1%) |
| Comorbidities | |||||||
| Prior Heart Failure | 33,480 (28.5%) |
10,595 (15.3%) |
7,664 (47.8%) |
15,221 (47.3%) |
4,162 (44.1%) |
6,356 (91.4%) |
10,477 (44.1%) |
| Prior PVD | 10,765 (9.2%) |
5,159 (7.5%) |
1,678 (10.5%) |
3,928 (12.2%) |
1,279 (13.6%) |
890 (12.8%) |
2,851 (12.0%) |
| Obesity | 12,463 (10.6%) |
7,332 (10.6%) |
1,591 (9.9%) |
3,540 (11.0%) |
884 (9.4%) |
899 (12.9%) |
2,600 (11.0%) |
| Prior MI | 5,674 (4.8%) |
2,614 (3.8%) |
1,156 (7.2%) |
1,904 (5.9%) |
540 (5.7%) |
490 (7.0%) |
1,409 (5.9%) |
| Hypertension | 68,397 (58.2%) |
37,905 (54.8%) |
10,740 (67.0%) |
19,752 (61.4%) |
5,741 (60.8%) |
4,245 (61.0%) |
14,741 (62.1%) |
| Dyslipidemia | 30,291 (25.8%) |
16,672 (24.1%) |
4,836 (30.2%) |
8,783 (27.3%) |
2,482 (26.3%) |
1,965 (28.3%) |
6,618 (27.9%) |
| Chronic Pulmonary Disease | 29,128 (24.8%) |
15,799 (22.8%) |
4,572 (28.5%) |
8,757 (27.2%) |
2,241 (23.8%) |
2,103 (30.2%) |
6,615 (27.9%) |
| Diabetes Mellitus | 30,276 (25.8%) |
17,378 (25.1%) |
4,759 (29.7) |
8,139 (25.3%) |
2,486 (26.4%) |
1,793 (25.8%) |
5,892 (24.8%) |
| DNR Status | 27,151 (23.1%) |
14,842 (21.4%) |
4,061 (25.4) |
8,248 (25.6%) |
2,375 (25.2%) |
1,513 (21.8%) |
6,340 (26.7%) |
| Acute Organ Failures | |||||||
| Total Number of Organ Failures, mean (SD) | 2.5 ± 1.4 | 2.3 ± 1.4 | 2.2 ± 1.3 | 2.9 ± 1.4 | 3.1 ± 1.4 | 2.8 ± 1.3 | 2.9 ± 1.4 |
| 0 | 4,389 (3.7%) |
3,197 (4.6%) |
693 (4.3) |
499 (1.6%) |
127 (1.4%) |
133 (1.9%) |
377 (1.6%) |
| 1 | 27,212 (23.2%) |
18,371 (26.5%) |
4,379 (27.3%) |
4,462 (13.9%) |
974 (10.3%) |
943 (13.6%) |
3,445 (14.5%) |
| 2 | 31,662 (27.0%) |
19,067 (27.6%) |
4,852 (30.3%) |
7,743 (24.1%) |
2,043 (21.7%) |
1,843 (26.5%) |
5,746 (24.2%) |
| ≥3 | 54,155 (46.1%) |
28,586 (41.3%) |
6,097 (38.1%) |
19,472 (60.5%) |
6,292 (66.7%) |
4,037 (58.0%) |
14,187 (59.7%) |
| Right Heart Catheterizati on | 786 (0.7%) |
224 (0.3%) |
84 (0.5%) |
478 (1.5%) |
142 (1.5%) |
138 (2.0%) |
346 (1.5%) |
| Pathogen Type | |||||||
| Gram Positive | 13,287 (11.3%) |
7,496 (10.8%) |
1,531 (9.6%) |
4,260 (13.2%) |
1,336 (14.2%) |
926 (13.3%) |
3,110 (13.1%) |
| Gram Negative | 20,759 (17.7%) |
12,760 (18.4%) |
2,504 (15.6%) |
5,495 (17.1%) |
1,534 (16.3%) |
1,222 (17.6%) |
4,040 (17.0%) |
| Fungal | 417 (0.4%) |
246 (0.4%) |
18 (0.1%) |
153 (0.5%) |
43 (0.5%) |
30 (0.4%) |
116 (0.5%) |
| Combination of Pathogens | 2,150 (1.8%) |
1,275 (1.8%) |
161 (1.0%) |
714 (2.2%) |
213 (2.3%) |
135 (1.9%) |
530 (2.2%) |
| None Specified | 80,805 (68.5%) |
47,444 (68.5%) |
11,807 (73.7%) |
21,554 (67.0%) |
6,310 (66.9%) |
4,643 (66.8%) |
15,959 (67.2%) |
| Source of Infection | |||||||
| Primary Bacteremia | 29,979 (25.5%) |
18,205 (26.3%) |
3,920 (24.5%) |
7,854 (24.4%) |
2,453 (26.0%) |
1,548 (22.2%) |
5,744 (24.2%) |
| No Primary Bacteremia | 87,439 (74.5%) |
51,016 (73.7%) |
12,101 (75.5%) |
24,322 (75.6%) |
6,983 (74.0%) |
5,408 (77.8%) |
18,011 (75.8%) |
| Septic Shock | 64,115 (54.6%) |
36,266 (52.4%) |
8,142 (50.8%) |
19,707 (61.3%) |
6,045 (64.1%) |
14,633 (61.6%) |
3,843 (55.3%) |
Data were presented in mean ± SD or n (%)
COPD: Chronic pulmonary disease, CV: Cardiovascular, DNR: Do not resuscitate, HF: Heart failure, MI: Myocardial infarction, PVD: Peripheral vascular disease.
Obesity was identified using ICD-9-CM code 278.00 and 278.01.
Dyslipidemia was identified using ICD-9-CM code 272.x (Disorders of lipid metabolism).