Table 1.

Genome-Wide Significant Signals Observed in GWAS of Iris Color in the Canadian South Asian Sample

GWAS-L-iris

Rsid

chr

Pos

NEA

EA

EAF

info

P value

Beta

SE

Gene

a-iris

b-iris

Delta-iris

Iris-mpheno

rs12898729

15

28392261

G

A

0.128

0.867

2.54E-14

0.900

0.113

HERC2

0.704

5.74E-07

4.25E-11

11.721

rs12913832

15

28365618

A

G

0.115

0.939

5.52E-14

0.904

0.115

HERC2

0.678

4.66E-07

5.08E-11

11.328

rs12916300

15

28410491

C

T

0.144

0.832

5.69E-14

0.880

0.112

HERC2

0.423

1.52E-07

1.91E-10

10.932

GWAS-a-iris

Rsid

chr

Pos

NEA

EA

EAF

info

P value

Beta

SE

Gene

L-iris

b-iris

Delta-iris

Iris-mpheno

rs28634972

10

126569229

C

G

0.250

0.940

3.11E-08

−0.513

0.090

0.282

9.21E-05

0.211

4.841

rs359899

2

185448231

A

C

0.155

0.973

5.70E-08

0.620

0.111

2.87E-04

3.45E-06

0.180

3.293

GWAS-b-iris

Rsid

chr

Pos

NEA

EA

EAF

info

P value

Beta

SE

Gene

L-iris

a-iris

Delta-iris

Iris-mpheno

rs1426654

15

48426484

A

G

0.150

0.956

8.49E-09

−0.594

0.100

SLC24A5

9.28E-04

2.16E-06

0.016

4.050

GWAS-delta-iris

Rsid

chr

Pos

NEA

EA

EAF

info

P value

Beta

SE

Gene

L-iris

a-iris

b-iris

Iris-mpheno

rs12898729

15

28392261

G

A

0.128

0.867

4.25E-11

0.788

0.115

HERC2

2.54E-14

0.704

5.74E-07

11.721

rs12913832

15

28365618

A

G

0.115

0.939

5.08E-11

0.798

0.117

HERC2

5.52E-14

0.678

4.66E-07

11.328

rs1129038

15

28356859

C

T

0.110

0.996

5.92E-11

0.794

0.117

GALNT12

6.37E-14

0.733

2.02E-06

10.951

^aGenome-wide significant after conditioning for rs12913832 and rs1426654 (P = 1.77E-8).