Table 3.
Risk of Adult Type 2 Diabetes in Relation to Overweight Status at Childhood and at Young Adult Age
| Childhood/Young Adult Overweight Status | Type 2 Diabetes | HR (95% CI) |
|---|---|---|
| Early type 2 diabetes (≤55.7 y of age; n = 36,176) | ||
| Normal weight/normal weight (n = 32,202) | 620 | 1 (reference) |
| Overweight/normal weight (n = 1,309) | 32 | 1.28 (0.89; 1.82) |
| Normal weight/overweight (n = 1,718) | 152 | 4.67 (3.90; 5.58) |
| Overweight/overweight (n = 947) | 85 | 4.82 (3.84; 6.05) |
| Late type 2 diabetes (>55.7 y of age; n = 26,015) | ||
| Normal weight/normal weight (n = 23,441) | 726 | 1 (reference) |
| Overweight/normal weight (n = 922) | 37 | 1.35 (0.97; 1.87) |
| Normal weight/overweight (n = 1,044) | 76 | 2.85 (2.25; 3.61) |
| Overweight/overweight (n = 608) | 49 | 3.04 (2.27; 4.06) |
HRs for type 2 diabetes were calculated using Cox proportional hazards regression. Normal weight/normal weight, not overweight at 8 or 20 y of age; Overweight/normal weight, overweight at 8 but not at 20 y of age; Normal weight/overweight, overweight at 20 but not at 8 y of age; Overweight/overweight, overweight both at 8 and 20 y of age. Childhood overweight at 8 y of age was defined as BMI ≥17.9 kg/m2 (21), whereas young adult overweight at 20 y of age was defined as BMI ≥25 kg/m2. The models have been adjusted for birth year and country of birth.