Fig 1. SB216763 induces lymphatic endothelial cell proliferation in a time and dose-dependent manner.

A) Primary human lung LECs in 1% FBS were incubated with vehicle or SB216763 at increasing concentration for 48 hours. B) LECs incubated with SB216763 (1μM) or vehicle (DMSO) demonstrated a time-dependent growth. Depicted are Mean ± SEM of 8 replicates. * P < 0.05, **P < 0.01, ***P < 0.001 by ANOVA. Results were repeated at least twice.