. 2019 Apr 9;14(4):e0215099. doi: 10.1371/journal.pone.0215099

Table 2. Overview of mucosal alterations.

	Time of treatment	Time of observation	Number of mice	Mucosa alteration		Inflammation	Hyperplasia	Dysplasia
	Time of treatment	Time of observation	Number of mice	Macroscopically	Histologically	Inflammation	Hyperplasia	Dysplasia
	1 day
kINPen 09	10 s	1d	14	14 (100) ^a	8 (57) ^a	14 (100) ^a	0 (0)	0 (0)
kINPen 09	60 s	1d	15	15 (100) ^a	6 (40) ^b,^c	15 (100) ^a	0 (0)	0 (0)
PS-MWM	10 s	1d	15	15 (100) ^a	13 (86) ^a,^c	15 (100) ^a	0 (0)	0 (0)
UV	8 s	1d	15	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
UV	48 s	1d	15	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Untreated	-	1d	15	0 (0) ^a	0 (0) ^a,^b	0 (0) ^a	0 (0)	0 (0)
	1 week
kINPen 09	10 s	1w	15	0 (0)	0 (0)	15 (100) ^a	0 (0)	0 (0)
kINPen 09	60 s	1w	14	0 (0)	0 (0)	14 (100) ^a	0 (0)	0 (0)
PS-MWM	10 s	1w	15	0 (0)	0 (0)	15 (100) ^a	0 (0)	0 (0)
UV	8 s	1w	15	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
UV	48 s	1w	15	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Untreated	-	1w	15	0 (0)	0 (0)	0 (0) ^a	0 (0)	0 (0)

Number and percentage of a mice with mucosa alterations (macroscopically and histologically) in the different treatment and control groups stratified for observation one day and one week after treatment. (s = seconds, percentage in brackets). Fisher-exact-test: Non-significant p-values are not reported.

a: p<0.001 untreated vs. treatment group.

b: p = 0.017 untreated vs. treatment group.

c: p = 0.021 kINPen09 vs. PS-MWM.