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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Curr Opin Biomed Eng. 2018 Aug 21;7:24–32. doi: 10.1016/j.cobme.2018.08.002

Figure 2. Schematic of gene editing machinery components that need to be encapsulated in delivery vehicles and their editing mechanisms.

Figure 2.

The components required for nuclease-mediated genome editing are shown on the left (CRISPR/Cas9 system), and the components required for TFO-mediated genome editing are shown on the right (PNA system). Approximate sizes of each of the components are indicated. Shown below the editing system components are the mechanisms of site-specific gene correction for each type of editing agent.