Illustration of the distribution of hydrophobic residues along the primary sequence of proteins with high vs. low clustering, of similar lengths and net hydrophobicities. The high clustering gene Fzd5 has length 585 amino acids, 31.5% hydrophobicity, and clustering of 1.58. The low clustering gene Farsb has length 589 amino acids, 31.6% hydrophobicity, and clustering of 0.69.