Figure 4.

Substitution rate $E\left[k_b\right]$ as a function of mean beneficial effect ${\overline{s}}_b$ for $u_d=5\times {10}^{-3}$ and $u_b={10}^{-12}$. The solid and dashed lines show the substitution rate (13) for $s_d\to 0$, while the points show the results obtained using (9) and (12) for $s_d={10}^{-3}$ (circles) and $5\times {10}^{-4}$ (squares). For $N={10}^{11}$, clonal interference occurs for ${\overline{s}}_b/u_d>0.73$, while it remains absent for all ${\overline{s}}_b$ for $N={10}^8$.