Odds Ratio: Biologic Use (95% CI)	p-value	Odds Ratio: Immunomodulator Use (95% CI)	p-value	Odds Ratio: 5-ASA Use (95% CI)	p-value	Odds Ratio: Corticosteroid Use (95% CI)	p-value	Odds Ratio Opioid Use (95% CI)	p-value
Gender
Female (referent)	-	-	-	-	-	-	-	-	-	-
Male	1.35 (1.20–1.52)	<0.001	0.98 (0.90–1.08)	0.72	1.24 (1.17–1.32)	<0.001	0.92 (0.87–0.98)	0.02	0.97 (0.92–1.04)	0.41
Region
Northeast (Referent)	-	-	-	-	-	-	-	-	-	-
North Central	1.23 (1.03–1.47)	0.03	1.57 (1.37–1.80)	<0.001	1.84 (1.67–2.02)	<0.001	1.68 (1.53–1.84)	<0.001	0.97 (0.92–1.04)	0.41
South	1.29 (1.10–1.52)	0.002	1.27 (1.12–1.45)	<0.001	1.43 (1.32–1.56)	<0.001	1.68 (1.54–1.82)	<0.001	1.80 (1.64–1.98)	<0.001
West	1.01 (0.83–1.23)	0.90	1.28 (1.10–1.49)	0.001	1.25 (1.13–1.38)	<0.001	1.12 (1.01–1.23)	0.03	1.90 (1.75–2.06)	<0.001
Unknown	1.11 (0.73–1.67)	0.64	0.87 (0.61–1.25)	0.45	0.79 (0.64–1.05)	0.02	0.85 (0.69–1.05)	0.14	1.06 (0.86–1.31)	0.58
Insurance Type
EPO/PPO (referent)	-	-	-	-	-	-	-	-	-	-
HMO/Cap POS	0.96 (0.80–1.16)	0.67	1.15 (1.01–1.32)	0.04	1.52 (1.38–1.67)	<0.001	1.32 (1.20–1.44)	<0.001	1.48 (1.34–1.62)	<0.001
POS	1.11 (0.91–1.36)	0.29	1.20 (1.02–1.40)	0.02	1.31 (1.17–1.46)	<0.001	1.32 (1.19–1.48)	<0.001	1.22 (1.10–1.37)	<0.001
HDHP/CDHP	1.28 (1.03–1.60)	0.03	1.02 (0.84–1.22)	0.87	1.38 (1.21–1.57)	<0.001	1.34 (1.18–1.52)	<0.001	1.16 (1.03–1.32)	0.02
Comp	0.81 (0.56–1.76)	0.25	1.14 (0.89–1.46)	0.30	1.44 (1.20–1.74)	<0.001	1.30 (1.09–1.55)	0.003	1.59 (1.33–1.90)	<0.001
Grouped Charlson Index
0 (referent)	-	-	-	-	-	-	-	-	-	-
1	1.56 (1.34–1.81)	<0.001	1.35 (1.20–1.51)	<0.001	0.94 (0.87–1.02)	0.14	1.47 (1.36–1.58)	<0.001	1.50 (1.39–1.62)	<0.001
2+	1.87 (1.63–2.15)	<0.001	1.65 (1.49–1.84)	<0.001	0.85 (0.79–0.92)	<0.001	1.46 (1.46–1.57)	<0.001	2.14 (1.99–2.30)	<0.001