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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Epidemiology. 2019 May;30(3):427–434. doi: 10.1097/EDE.0000000000000976

Table 2.

Association between Vitamin A, C, and E intake and adjusted probability of clinical assisted reproductive technology outcomes

Vitamin A total intake (range, mcg/day)
Clinical outcomes Q1 (<1419.6) Q2 (1419.6–1874.1) Q3 (1874.6–2285.7) Q4 (>2285.7) P for trend
 Implantation 0.43 (0.33–0.54) 0.50 (0.40–0.59) 0.57 (0.47–0.67) 0.50 (0.40–0.61) 0.25
 Clinical pregnancy 0.34 (0.25–0.44) 0.43 (0.34–0.52) 0.51 (0.41–0.60) 0.44 (0.35–0.55) 0.11
 Live birth 0.25 (0.17–0.35) 0.38 (0.29–0.47) 0.36 (0.28–0.46) 0.31 (0.23–0.42) 0.38
Vitamin A from foods (range, mcg/day)
Clinical outcomes Q1 (<671.2) Q2 (671.2–835.3) Q3 (847.6–1067.6) Q4 (>1067.6) P for trend
 Implantation 0.55 (0.45–0.65) 0.50 (0.41–0.59) 0.48 (0.39–0.58) 0.47 (0.38–0.57) 0.29
 Clinical pregnancy 0.46 (0.37–0.56) 0.43 (0.34–0.52) 0.42 (0.33–0.51) 0.42 (0.33–0.52) 0.57
 Live birth 0.34 (0.25–0.44) 0.34 (0.26–0.43) 0.32 (0.24–0.42) 0.31 (0.23–0.41) 0.66
Vitamin A from supplements (range, mcg/day)
Clinical outcomes Q1 (<598.5) Q2 (598.5–900.0) Q3 (900.0–1200.0) Q4 (>1200.0) P for trend
 Implantation 0.54 (0.38–0.69) 0.51 (0.42–0.60) 0.46 (0.34–0.57) 0.50 (0.39–0.60) 0.74
 Clinical pregnancy 0.44 (0.29–0.59) 0.46 (0.37–0.54) 0.40 (0.29–0.51) 0.43 (0.33–0.53) 0.94
 Live birth 0.37 (0.24–0.53) 0.38 (0.30–0.47) 0.27 (0.19–0.38) 0.28 (0.19–0.37) 0.29
Vitamin C total intake (range, mg/day)
Clinical outcomes Q1 (<132.9) Q2 (132.9–185.6) Q3 (185.8–250.0) Q4 (>250.0) P for trend
 Implantation 0.46 (0.35–0.56) 0.53 (0.43–0.62) 0.53 (0.44–0.62) 0.49 (0.39–0.59) 0.98
 Clinical pregnancy 0.40 (0.30–0.50) 0.45 (0.36–0.54) 0.46 (0.37–0.55) 0.41 (0.32–0.51) 0.94
 Live birth 0.30 (0.21–0.40) 0.35 (0.26–0.44) 0.34 (0.26–0.43) 0.32 (0.24–0.42) 0.99
Vitamin C from foods (range, mg/day)
Clinical outcomes Q1 (<66.7) Q2 (66.7–88.5) Q3 (89.3–125.2) Q4 (>125.2) P for trend
 Implantation 0.50 (0.40–0.60) 0.52 (0.42–0.62) 0.48 (0.39–0.57) 0.52 (0.42–0.62) 0.86
 Clinical pregnancy 0.40 (0.31–0.49) 0.46 (0.37–0.56) 0.41 (0.33–0.50) 0.46 (0.36–0.56) 0.52
 Live birth 0.32 (0.24–0.41) 0.36 (0.28–0.46) 0.28 (0.21–0.37) 0.35 (0.26–0.45) 0.85
Vitamin C from supplements (range, mg/day)
Clinical outcomes Q1 (<60.0) Q2 (60.0–68.6) Q3 (68.6–120.0) Q4 (>120.0) P for trend
 Implantation 0.47 (0.35–.059) 0.56 (0.46–0.66) 0.50 (0.41–0.60) 0.48 (0.38–0.58) 0.56
 Clinical pregnancy 0.41 (0.30–0.53) 0.50 (0.41–0.60) 0.44 (0.35–0.53) 0.37 (0.28–0.47) 0.18
 Live birth 0.27 (0.18–0.38) 0.39 (0.30–0.49) 0.36 (0.28–0.46) 0.28 (0.20–0.37) 0.39
Vitamin E total intake (range, mg/day)
Clinical outcomes Q1 (<15.9) Q2 (15.9–20.4) Q3 (20.4–24.6) Q4 (>24.6) P for trend
 Implantation 0.51 (0.40–0.62) 0.53 (0.44–0.62) 0.48 (0.38–0.58) 0.48 (0.37–0.59) 0.65
 Clinical pregnancy 0.49 (0.38–0.60) 0.45 (0.36–0.54) 0.38 (0.29–0.48) 0.39 (0.30–0.50) 0.24
 Live birth 0.38 (0.27–0.50) 0.35 (0.27–0.44) 0.28 (0.20–0.37) 0.29 (0.21–0.39) 0.26
Vitamin E from foods (range, mg/day)
Clinical outcomes Q1 (<6.6) Q2 (6.6–8.3) Q3 (8.4–10.3) Q4 (>10.3) P for trend
 Implantation 0.48 (0.39–0.58) 0.50 (0.41–0.60) 0.56 (0.46–0.65) 0.47 (0.37–0.57) 0.78
 Clinical pregnancy 0.43 (0.34–0.52) 0.42 (0.34–0.52) 0.51 (0.41–0.60) 0.37 (0.29–0.47) 0.42
 Live birth 0.33 (0.24–0.42) 0.31 (0.23–0.40) 0.40 (0.32–0.50) 0.27 (0.19–0.36) 0.39
Vitamin E from supplements (range, mg/day)
Clinical outcomes Q1 (<7.7) Q2 (7.7–13.5) Q3 (13.5–13.5) Q4 (>13.5) P for trend
 Implantation 0.43 (0.30–0.58) 0.50 (0.40–0.59) 0.54 (0.43–0.64) 0.55 (0.43–0.66) 0.30
 Clinical pregnancy 0.39 (0.26–0.54) 0.43 (0.34–0.52) 0.44 (0.34–0.55) 0.47 (0.36–0.59) 0.49
 Live birth 0.28 (0.17–0.41) 0.31 (0.24–0.40) 0.33 (0.24–0.43) 0.40 (0.29–0.52) 0.29

Data presented are adjusted probability of clinical outcomes and 95% confidence interval.

All models were adjusted for the other two antioxidants, age, body mass index, smoking, folate, vitamin b12, total calorie intake, the Prudent and Western dietary pattern, and treatment protocol.