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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Epidemiology. 2019 May;30(3):358–364. doi: 10.1097/EDE.0000000000000966

Table 1.

Distributions of key variables across 2000 simulations in the higher HIV incidence African setting and lower incidence US setting

Variable African Trials
(trial n=4000)
 US Trials
(trial n=500)
Median (%) IQR (%) Median (%) IQR (%)
Randomization to PrEP 50.0 49.5, 50.5 50.0 48.6, 51.4
Receipt of PrEP 24.9 24.4, 25.4 37.0 35.4, 38.4
Incident HIV 4.2 4.0, 4.4 0.4 0.2, 0.8
Age >21 yearsa 33.3 32.9, 33.9 66.6 65.4, 68.2
No STI at baselineb 79.0 78.6, 79.4 89.0 88.2, 90.0

Abbreviations: HIV, human immunodeficiency virus; US, United States; n: sample size; IQR, interquartile range; PrEP, pre-exposure prophylaxis; STI: sexually transmitted infection (other than herpes simplex virus)

a

African age distribution based on references 6 and 10. US age distribution based on references 4 and 11.

b

African distribution based on reference 10, and US distribution based on reference 12.