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. Author manuscript; available in PMC: 2020 Apr 16.
Published in final edited form as: Angew Chem Int Ed Engl. 2019 Mar 21;58(17):5567–5571. doi: 10.1002/anie.201812998

Figure 1. iA as context-dependent signals for cell death and cell morphogenesis.

Figure 1.

(A) Molecular structures of NapFFpYGGaa (1P, Nap: naphthylacetic acid; F: L-phenylalanine; pY: L-phosphotyrosine; G: glycine; a: D-alanine), vancomycin (2), and their non-covalent complex 1P:2. (B) Illustration of the context-dependent dynamic continuum of molecular assemblies for controlling cell fate. By controlling the activity of the ectophosphatase (e.g., ALPL) on cancer cells via a corresponding enzyme inhibitor, dynamic continuum of the assemblies of supramolecular phosphoglycopeptides (sPGP) resulting in a 2D cell sheet, 3D cell spheroids, or cell death.