Table 2.
Prevalence of reported drug-induced severe cutaneous adverse reactions by patient demographic characteristics
| Total n (%) |
Sexa n (%) |
Racial/ethnic group b n (%) |
||||||
|---|---|---|---|---|---|---|---|---|
| n=2,734,506 | Femalec
n=1,511,555 |
Male n=1,222,649 |
Whited
n=1,814,521 |
Blacke
n=156,892 |
Hispanicf
n=171,071 |
Asiang
n=94,332 |
Other n=47,028 |
|
| Patients with SCAR | 1,122 (0.04) | 674 (0.05) | 448 (0.04) | 824 (0.05) | 57 (0.04) | 37 (0.02) | 50 (0.05) | 15 (0.03) |
| AGEP | 7 (0.0) | 4 (0.0) | 3 (0.0) | 5 (0.0) | 0 | 0 | 2 (0.0) | 0 |
| DRESS | 55 (0.002) | 33 (0.002) | 22 (0.002) | 41 (0.002) | 5 (0.003) | 4 (0.002) | 3 (0.003) | 0 |
| EM | 259 (0.009) | 135 (0.009) | 124 (0.01) | 176 (0.01) | 5 (0.003) | 10 (0.006) | 8 (0.008) | 5 (0.001) |
| SJS | 755 (0.03) | 481 (0.03) | 274 (0.02) | 582 (0.03) | 42 (0.03) | 22 (0.01) | 33 (0.04) | 9 (0.02) |
| TEN | 77 (0.003) | 44 (0.003) | 33 (0.003) | 45 (0.002) | 9 (0.006) | 3 (0.002) | 6 (0.006) | 1 (0.002) |
AGEP = acute generalized exanthematous pustulosis; DRESS = drug reaction with eosinophilia and systemic symptoms; EM = erythema multiforme; SCAR = severe cutaneous adverse reaction; SJS = Stevens-Johnson syndrome; TEN = toxic epidermal necrolysis
Sex information for patients with an HSR was missing for 302 patients
Race information for patients with an HSR was missing (e.g., unknown, refused) for 44,599 patients
SCAR and SJS were significantly (p<0.05) more prevalent in females than males
White patients had a significantly (p<0.05) higher prevalence of SCAR and all subtypes, except for AGEP (p>0.05), compared to the rest of the PEAR population
Black patients had a significantly (p<0.05) higher prevalence of DRESS and TEN, compared to the rest of the PEAR population; Black patients had a significantly (p<0.05) lower prevalence of SCAR, EM, and SJS, compared to the rest of the PEAR population
Hispanic patients had a significantly (p<0.05) higher prevalence of DRESS, compared to the rest of the PEAR population; Hispanic patients had a significantly (p<0.05) lower prevalence of SCAR, EM, SJS, and TEN compared to the rest of the PEAR population
Asian patients had a significantly (p<0.05) higher prevalence of SCAR, DRESS, SJS, and TEN, compared to the rest of the PEAR population; Asian patients had a significantly (p<0.05) lower prevalence of EM, compared to the rest of the PEAR population