Table E2.
Immediate Hypersensitivity Reaction and Top Five Causative Drugs by Drug Category
| Rank | Itching (n=46,200) |
Hives/ Urticaria (n=150,450) |
Respiratory (n=34,307) |
Angioedema/ Swelling (n=43,600) |
Anaphylaxis/Arrest/Asystole/ Hypotension/Shock (n=33,736) |
|---|---|---|---|---|---|
| 1 | PCN – Naturala
(6,544, 14.2) |
PCN – Naturala
(51,325, 34.1) |
PCN – Naturala
(5,600, 16.3) |
PCN – Naturala
(9,568, 21.9) |
PCN – Naturala
(11,236, 33.5) |
| 2 | Sulfa ABX/ SMX-TMP (5,709, 12.4) |
Sulfa ABX/ SMX-TMP (28,491, 18.9) |
Sulfa ABX/ SMX-TMP (3,247, 9.5) |
Sulfa ABX/ SMX-TMP (5,602, 12.8) |
Sulfa ABX/ SMX-TMP (3,953, 11.8) |
| 3 | Analgesic Narcotic Agonistsb
(5,591, 12.1) |
Aminopenicillin Antibioticd (10,132, 6.7) |
Analgesic Narcotic Agonistsb
(3,114, 9.1) |
NSAID (COX Non-Specific)e
(3,343, 7.7) |
Analgesic Narcotic Agonistsb
(2,128, 6.4) |
| 4 | Analgesic Narcotic Oxycodone Combinationsc
(3,000, 6.5) |
NSAID (COX Non-Specific)e
(5,112, 3.4) |
NSAID (COX Non-Specific)e
(2,312, 6.7) |
ACE Inhibitors (2,751, 6.3) |
NSAID (COX Non-Specific)e
(1,675, 5.0) |
| 5 | Fluoroquinolone (1,619, 3.5) |
Analgesic Narcotic Agonistsb
(3,930, 2.6) |
ACE Inhibitors (1,544, 4.5) |
Fluoroquinolone (1,533, 3.5) |
Fluoroquinolone (1,046, 3.1) |
ABX = antibiotic; ACE = angiotensin-converting enzyme; COX = cyclooxygenase; NMB = neuromuscular blocker; NSAID = non-steroidal anti-inflammatory drugs; PCN = penicillin; SMX-TMP = sulfamethoxazole-trimethoprim
a
Includes penicillin G, penicillin V
b
Includes morphine, oxycodone
c
Includes oxycodone-acetaminophen
d
Includes amoxicillin, ampicillin
e
Includes ibuprofen, naproxen