Table E3.

Non-immediate Hypersensitivity Reaction and Top Five Causative Drugs by Drug Category

Rank	Dermatitis/Rash (n=269,493)	Fixed drug eruption (n=86)	Erythema nodosum (n=86)	Serum sickness (n=521)	Pneumonitis (n=120)	AIN (n=442)	SCAR (n=1,415)
1	PCN – Naturala (81,219, 30.1)	Sulfa ABX/ SMX-TMP (21, 24.4)	Tetracycline Antibiotics (15, 17.4)	PCN – Naturala (149, 28.6)	Methotrexate (27, 22.5)	PCN -Penicillinase-resistanth (89, 20.1)	Sulfa ABX/ SMX-TMP (360, 25.4)
2	Sulfa ABX/ SMX-TMP (55,916, 20.7)	NSAID (COX Non-Specific)c (16, 18.6)	PCN – Naturala (13, 15.1)	Sulfa ABX/ SMX-TMP (81, 15.5)	Urinary Antibacterial - Nitrofuran Derivativese (23, 19.2)	PCN – Naturala (54, 12.2)	PCN – Naturala (169, 11.9)
3	Aminopenicillin Antibioticb (19,724, 7.2)	Antifungal – Triazolesd (9, 10.5)	Sulfa ABX/ SMX-TMP (12, 14.0)	Aminopenicillin Antibioticb (60, 11.5)	Antineoplastic - Taxanes (13, 10.8)	Sulfa ABX/ SMX-TMP (46, 10.4)	Anticonvulsant - Phenyltriazine Derivativesi (69, 4.9)
4	Fluoroquinolone (7,879, 2.9)	Fluoroquinolone (8, 9.3)	Oral Contraceptive (10, 11.6)	Cephalosporin Antibiotics -2nd Generationj (31, 6.0)	Anti-arrhythmic - Class IIIf (6, 5.0)	PPI (46, 10.4)	Aminopenicillin Antibioticb (67, 4.7)
5	Tetracycline Antibiotics (6,345, 2.4)	Tetracycline Antibiotics (6, 7.0)	Fluoroquinolone (3, 3.5)	Tetracycline Antibiotics (30, 5.8)	Antineoplastic – Antiandrogensg (3, 2.5)	Fluoroquinolone (31, 7.0)	Anticonvulsant – Hydantoinsj (57, 4.0)

ABX = antibiotic; AIN = acute interstitial nephritis; PCN = penicillin; PPI = proton pump inhibitor; SCAR = severe cutaneous adverse reaction; SMX-TMP = sulfamethoxazole-trimethoprim

^aIncludes penicillin G, penicillin V

^bIncludes amoxicillin, ampicillin

^cIncludes ibuprofen, naproxen

^dIncludes fluconazole, voriconazole

^eIncludes nitrofurantoin

^fIncludes amiodarone, dofetilide

^gIncludes bicalutamide, nilutamide

^hIncludes nafcillin, oxacillin

ⁱIncludes lamotrigine

^jIncludes fosphenytoin, phenytoin