Table 3.

Associations between infertility and ovarian cancer incidence

	Cancer cases	Person-years	Age-adjusted		Multivariablea
			HR (95% CI)	p value	HR (95% CI)	p value
Infertility
No infertility	6060	64,479,845	1.00 (reference)	.	1.00 (reference)	.
Infertility	375	1,739,692	1.73 (1.56–1.92)	< 0.001	1.53 (1.38–1.71)	< 0.001
Infertility and related diagnoses
No diagnosis	5793	63,340,911	1.00 (reference)	.	1.00 (reference)	.
Ovulatory disturbances	58	371,256	1.53 (1.18–1.98)	0.001	1.53 (1.18–1.98)	0.001
Endometriosis	209	767,678	1.55 (1.35–1.78)	< 0.001	1.77 (1.53–2.05)	< 0.001
Infertility	299	1,393,212	1.71 (1.52–1.92)	< 0.001	1.53 (1.36–1.72)	< 0.001
Infertility and ovulatory disturbances	15	152,397	1.15 (0.69–1.91)	0.589	1.12 (0.68–1.87)	0.651
Infertility and endometriosis	61	194,084	2.38 (1.85–3.06)	< 0.001	2.19 (1.70–2.82)	< 0.001

p < 0.05 is significant in all analyses. The dots represent the reference category

^aAdjusted for age, calendar time, education level, country of birth, parity and age at first birth, salpingectomy and hysterectomy