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Model of mechanisms of regulation of KLF8 via phosphorylation and ubiquitylation. In the nucleus, ERK2 phosphorylates KLF8 which creates the pS48P motif. This motif recruits NEDD4 by binding to the WW domain which enables NEDD4 to add a ubiquitin to KLF8. This modification of the phosphorylated form of KLF8 plays a role in retaining the overall stability and function of KLF8 protein in the nucleus.
