Figure 6.

IL-27 prevents LPS-induced inflammatory osteolysis in vivo. A-C. The expression levels of TNF-α, IL-1β, and IL-6 in mouse serum were analyzed using an ELISA kit. D. Three-dimensional images of whole skulls were reconstructed using a micro-CT scanner. E, F. Quantitative analysis of bone volume/total volume (BV/TV) and percentage of resorption area (%). G. H&E staining of sections of skull samples from 6-week-old C57BL/6 mice treated with PBS, LPS, and LPS + IL-27. (*P < 0.05, **P < 0.01).