Table 4.
Variables associated with overall survival according to the cox proportional hazards model
| Variable | Univariable Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (>60 years) | 0.80 | 0.52, 1.23 | 0.302 | |||
| Gender (Female) | 0.82 | 0.46, 1.46 | 0.508 | |||
| Hemoglobin (>120 g/L) | 0.54 | 0.36, 0.82 | 0.003 | 0.50 | 0.33, 0.78 | 0.002 |
| Albumin (>35 g/L) | 0.38 | 0.25, 0.60 | <0.001 | |||
| Total bilirubin (>34.2 mmol/L) | 2.50 | 0.96, 7.03 | 0.061 | |||
| ALT (>40 U/L) | 1.82 | 1.27, 2.60 | 0.001 | |||
| AST (>40 U/L) | 2.38 | 1.67, 3.38 | <0.001 | 1.69 | 1.15, 2.47 | 0.007 |
| GGT (>50 U/L) | 2.20 | 1.54, 3.15 | <0.001 | 1.54 | 1.05, 2.27 | 0.028 |
| PT (>14 s) | 2.23 | 1.37, 3.62 | 0.001 | 1.95 | 1.18, 3.22 | 0.009 |
| HBV positive | 1.51 | 0.76, 2.97 | 0.236 | |||
| HCV positive | 1.66 | 0.61, 4.50 | 0.322 | |||
| BCLC stage of primary tumor (B-C) | 1.74 | 1.23, 2.48 | 0.002 | |||
| BCLC stage of recurrent tumor (B-C) | 2.66 | 1.84, 3.85 | <0.001 | 1.57 | 1.02, 2.41 | 0.038 |
| Macrovascular invasion | 2.94 | 1.85, 4.66 | <0.001 | 1.66 | 1.00, 2.75 | 0.048 |
| Treatment for rHCC | ||||||
| TACE | 1.00 | |||||
| RR/RFA | 0.35 | 0.24, 0.52 | <0.001 | 0.60 | 0.38, 0.93 | 0.022 |
| Platelet (>100×109/L) | 1.28 | 0.81, 2.01 | 0.287 | |||
| AFP (>200 ug/L) | 1.79 | 1.27, 2.53 | 0.001 | |||
| Child-Pugh classification B | 4.14 | 2.09, 8.19 | <0.001 | |||
| Tumor size (>5 cm) | 1.91 | 1.17, 3.12 | 0.009 | |||
| Tumor number (>1) | 2.09 | 1.45, 3.02 | <0.001 | |||
| TTR (≥1 year) | 0.23 | 0.10, 0.51 | <0.001 | 0.28 | 0.12, 0.66 | 0.003 |
Abbreviations: ALT (alanine transaminase), AST (aspartate aminotransferase), GGT (glutamyl transpeptidase), PT (prothrombin time), HBV (hepatitis B virus), AFP (alpha fetal protein), TTR (time to recurrence).