Figure 2.

Pirfenidone inhibited collagen secretion. A. Histological images of collagen tissue hyperplasia in the laminectomy sites of rats treated with saline or pirfenidone (10 mg/ml, 40 mg/ml, and 80 mg/ml). The collagen density in scar tissue decreased with the increasing of pirfenidone concentration. B. The area of scar tissue for each rat was defined as the mean scar area of six sections and the data are expressed as means ± standard deviation (SD) in mm². *P<0.05, ***P<0.001 versus the area of scar tissue in the control group. ##P<0.01, ###P<0.001 versus the 10-mg/ml pirfenidone-treated group. The magnification used was 200 ×.