Figure 1.

CBX2 is upregulated in breast tumors and CBX2 expression is associated with prognosis of breast cancer patients in TCGA dataset. A. Comparison of CBX2 mRNA expression between breast cancers and normal tissues in the TCGA dataset. B. Comparison of CBX2 mRNA expression in breast cancers of different molecular subtypes. CBX2 was upregulated in Basal-like and Her2-enriched subtypes compared to LumA and LumB subtypes. C, D. Elevated CBX2 mRNA expression was observed in ER- and PR-negative breast cancer tissues. E. CBX2 mRNA expression in breast tumor tissues according to TNM stage. F. Analysis of the correlation between CBX2 expression and Ki-67 expression. G, H. Kaplan-Meier survival curves showing stratification of breast cancer patients in TCGA dataset based on CBX2 expression (red: high CBX2 expression; green: low CBX2 expression). Breast cancer patients with high CBX2 expression had markedly shorter OS and PFS time than those with low CBX2 expression. *P<0.05, **P<0.01.