Figure 2.

The bladder morphology of SMA mice. A. Normalized bladder mass to body mass. SMA mouse bladder is 50% smaller as compared to WT (0.6589 ± 0.03764 N=7 vs 1.285 ± 0.1773 N=7, P=0.0015). B. Representative images of bladder smooth muscles stained for dystrophin. C. Quantification of bladder smooth muscle CSA. No difference was observed in bladder smooth muscle CSA between SMA and WT (15.41 ± 1.691 µm² N=5 vs 20.94 ± 2.557 µm² N=5, P=0.1086), but with a significant shift in distribution towards smaller CSA smooth muscle cells (Kolmogorov-Smirnov D=0.1647, P < 0.0001).