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. 2019 Mar 15;11(3):1498–1509.

Figure 3.

Figure 3

LXR is a downstream target of AMPK. To clarify the relation between AMPK and LXR, pretreatment with LXR siRNA was applied in HepG2 cells exposed to FFA + recombinant fetuin B. Pretreatment with AMPK agonist (AICAR, 1 mM) was applied to HepG2 cells exposed to FFA + recombinant fetuin B. A: Intercellular TG content: FFA + Rec vs. FFA + Rec + siLXR (P = 0.003); B: The expression of key proteins in the AMPK and LXR pathways; C: The mRNA levels of lipid metabolic enzymes; D: Intercellular TG content: FFA + Rec FetB vs. FFA + Rec FetB + AICAR (P < 0.001); E: The expression of key proteins in the AMPK AND LXR pathways; F: The mRNA levels of lipid metabolic enzymes; Rec, Recombinant fetuin B; siLXR, siRNA LXR. Results are the mean ± SD of three independent experiments, each repeated in triplicate.